Excerpt from Granuloma Faciale

Synonyms, Key Words, and Related Terms: GF, granuloma faciale eosinophilicum, granuloma faciale with eosinophilia

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Background

Granuloma faciale (GF) is an uncommon benign chronic skin disease of unknown origin characterized by single or multiple cutaneous nodules, usually occurring over the face. Occasionally, extrafacial involvement is noted,^{1, 2, 3, 4} most often on sun-exposed areas. Lever and Leeper first recognized GF as a distinct entity in 1950. Pinkus' group suggested the name granuloma faciale that same year. The disease mimics many other dermatoses and can be confused with conditions, such as sarcoidosis, discoid lupus erythematosus, mycosis fungoides, and fixed drug eruption. See Sarcoidosis; Lupus Erythematosus, Discoid; Mycosis Fungoides; and Fixed Drug Eruptions for more information on these topics.

Pathophysiology

The skin is the primary organ system that is affected. Reports of GF-like lesions of the oral mucosa are rare.⁵

Frequency

United States

Cases of GF are rare.

Race

GF is found most commonly in whites; however, it has been reported rarely in Japanese and blacks.

Sex

Men are affected more frequently than women.

Age

GF is primarily a disease of middle age (median age, 45 y).

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