News & Perspective
Drugs & Diseases
CME & Education
Video
Decision Point
Edition: English

Medscape

English
Deutsch
Español
Français
Português
UKNew

Univadis

Français New
Italiano New
Sign Up It's Free!
English Edition

Medscape

Univadis

X
Univadis from Medscape

No Results

    News & Perspective Drugs & Diseases CME & Education Video Decision Point
    Drugs & Diseases>Emergency Medicine

    Osteomyelitis in Emergency Medicine

    Updated: Nov 02, 2022
    • Author: Randall W King, MD, FACEP; Chief Editor: Jeter (Jay) Pritchard Taylor, III, MD  more...
    • Print
    Overview

    Background

    Osteomyelitis is an acute or chronic inflammatory process of the bone and its structures secondary to infection with pyogenic organisms. [1]

    Next: Pathophysiology

    Pathophysiology

    Osteomyelitis may be localized or it may spread through the periosteum, cortex, marrow, and cancellous tissue. The bacterial pathogen varies on the basis of the patient's age and the mechanism of infection.

    The following are the 2 primary categories of acute osteomyelitis: hematogenous osteomyelitis and direct or contiguous inoculation osteomyelitis.

    Hematogenous osteomyelitis is an infection caused by bacterial seeding from the blood. Acute hematogenous osteomyelitis is characterized by an acute infection of the bone caused by the seeding of the bacteria within the bone from a remote source. This condition primarily occurs in children. The most common site is the rapidly growing and highly vascular metaphysis of growing bones. The apparent slowing or sludging of blood flow as the vessels make sharp angles at the distal metaphysis predisposes the vessels to thrombosis and the bone itself to localized necrosis and bacterial seeding.

    Vertebral osteomyelitis at any age is most often a secondary complication of a remote infection with hematogenous seeding. In approximately one half of vertebral osteomyelitis cases, a source can be identified such as urinary tract or skin, and approximately one third may be diagnosed with endocarditis. [2] Acute hematogenous osteomyelitis, despite its name, may have a slow clinical development and insidious onset.

    Direct or contiguous inoculation osteomyelitis is caused by direct contact of the tissue and bacteria during trauma or surgery. Direct inoculation (contiguous-focus) osteomyelitis is an infection in the bone secondary to the inoculation of organisms from direct trauma, spread from a contiguous focus of infection, or sepsis after a surgical procedure. Clinical manifestations of direct inoculation osteomyelitis are more localized than those of hematogenous osteomyelitis and tend to involve multiple organisms.

    Additional categories include chronic osteomyelitis and osteomyelitis secondary to peripheral vascular disease. Chronic osteomyelitis persists or recurs, regardless of its initial cause and/or mechanism and despite aggressive intervention. Although listed as an etiology, peripheral vascular disease is actually a predisposing factor rather than a true cause of infection.

    Disease states known to predispose patients to osteomyelitis include diabetes mellitus, [3]  sickle cell disease, acquired immune deficiency syndrome (AIDS), intravenous (IV) drug abuse, alcoholism, chronic steroid use, immunosuppression, and chronic joint disease. In addition, the presence of a prosthetic orthopedic device is an independent risk factor, as is any recent orthopedic surgery or open fracture.

    For the radiologic perspective, see Osteomyelitis, Acute Pyogenic and Osteomyelitis, Chronic.

    Previous
    Next: Pathophysiology

    Epidemiology

    Frequency

    United States

    The overall prevalence is 1 case per 5,000 children. Neonatal prevalence is approximately 1 case per 1,000. The annual incidence in patients with sickle cell anemia is approximately 0.36%. The prevalence of osteomyelitis after foot puncture (as is seen in the image below) may be as high as 16% (30-40% in patients with diabetes). The incidence of vertebral osteomyelitis is approximately 2.4 cases per 100,000 population. [2]

    Osteomyelitis of diabetic foot. Photography by DavOsteomyelitis of diabetic foot. Photography by David Effron MD, FACEP.
    View Media Gallery

    International

    The overall incidence is higher in developing countries.

    Mortality/Morbidity

    Morbidity can be significant and can include localized spread of infection to associated soft tissues or joints; evolution to chronic infection, with pain and disability; amputation of the involved extremity; generalized infection; or sepsis. As many as 10-15% of patients with vertebral osteomyelitis develop neurologic findings or frank spinal-cord compression. As many as 30% of pediatric patients with long-bone osteomyelitis may develop deep venous thrombosis (DVT). The development of DVT may also be a marker for disseminated infection. [4, 5] Vascular complications appear to be more common with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) than was previously recognized. [1, 6]

    Mortality rates are low, unless associated sepsis or an underlying serious medical condition is present.

    Race

    No increased incidence of osteomyelitis is noted based on race.

    Sex

    Males are at increased relative risk, which increases through childhood, peaking in adolescence and falling to a low ratio in adults. [7]

    Age

    In general, osteomyelitis has a bimodal age distribution. Acute hematogenous osteomyelitis is primarily a disease in children. Direct trauma and contiguous focus osteomyelitis are more common among adults and adolescents than in children. Vertebral osteomyelitis is more common in persons older than 45 years.

    Previous
    Next: Pathophysiology

    Prognosis

    The prognosis for osteomyelitis varies but is markedly improved with timely diagnosis and aggressive therapeutic intervention.

    Previous
    Clinical Presentation
     
     
    Media Gallery
    of 7
    Find Us On
    About
    About Medscape Privacy Policy Editorial Policy Cookies Manage Preferences Terms of Use Advertising Policy Help Center
    Membership
    Become a Member About You Professional Information Newsletters & Alerts Advertise Market Research
    App
    Medscape
    Editions
    English Deutsch Español Français Português
    All material on this website is protected by copyright, Copyright © 1994-2025 by WebMD LLC. This website also contains material copyrighted by 3rd parties.