AUTHOR AND EDITOR INFORMATION

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INTRODUCTION

Section 2 of 11  

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• Introduction
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• Miscellaneous
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Background

Scabies is a common parasitic infection of global proportion. Worldwide, an estimated 300 million cases occur annually. The arthropod Sarcoptes scabiei var hominis causes an intensely pruritic and highly contagious skin infestation, which affects males and females of all socioeconomic stratas and all ethnic groups.

Scabies has been reported for more than 2500 years. Aristotle discussed "lice in the flesh," which resulted in vesicles, and Celsus recommended sulfur mixed with liquid pitch as a remedy for the disease. However, the disease was first ascribed to the mite by Giovan Cosimo Bonomo in 1687. It was the first human disease recognized to be caused by a specific pathogen.

Pathophysiology

The scabies mite is an obligate parasite and completes its entire life cycle on humans. Other variants of the scabies mite can cause infestation in other mammals such as dogs, cats, pigs, ferrets, and horses, and these variants can infest human skin as well. However, they are unable to reproduce in humans and only cause a transient dermatitis.

The S scabiei var hominis mite that infects humans is female and can just be seen with the naked eye (0.3-0.4 mm long). The male is about one half this size. The male fertilizes the female on human skin and then dies. Newly mated females burrow into human skin, using proteolytic enzymes to dissolve the stratum corneum of the epidermis. The mite has 4 pairs of legs and tracheal breaths and thus does not penetrate deeper than the outer layer of the epidermis.

The female deposits eggs in the burrows, and then the eggs incubate and hatch after 3-5 days (range up to 8 d). About 90% of the hatched mites die, but those that survive go through various molting stages and reach maturity after a little more than 2 weeks. The female adults, who never leave their burrows, die after 1-2 months.

In a classic scabies infection, anywhere from 5-15 mites (range, 3-50) live on the host. Little evidence of infection exists during the first month (range, 2-6 wk), but after 4 weeks and with subsequent infections, a delayed-type IV hypersensitivity reaction to the mites, eggs, and scybala (packet of feces) occurs. The time required to induce immunity in primary infestations probably accounts for the latent period of 4 weeks of asymptomatic infection. In reinfestation, the sensitized individual may develop a reaction rapidly (within hours). The resultant skin eruption, and its associated intense pruritus, is the hallmark of classic scabies.

Crusted, or Norwegian scabies (so named because the first description was from Norway in the mid 1800s), is a distinctive and highly contagious form of scabies. In this variant, hundreds to millions of mites infest the host individual, who is usually immunocompromised, elderly, or physically and/or mentally disabled and impaired. Extensive, widespread, crusted lesions appear with thick, hyperkeratotic scales over the elbows, knees, palms, and soles. Serum immunoglobulin E (IgE) and immunoglobulin G (IgG) levels are extremely high in these patients, yet the immune reaction does not seem to be protective. Cell-mediated immunity in classic scabies demonstrates a predominantly CD4 T-cell infiltrate in the skin, while one study suggests a CD8 predominance in crusted scabies.

Atypical infestations may also befall the very young (neonates).

Frequency and epidemiology

While many accounts of the epidemiology of scabies suggest that epidemics or pandemics occur in 30-year cycles, this may be an oversimplification of its incidence. These accounts coincided with the major wars of the 20th century. Because it is not a reportable disease, and data are based on variable notification, the incidence of scabies is difficult to ascertain. Indeed, while epidemics have been reported (1919-1925, 1936-1949, 1964-1979), it is clearly an endemic disease in many tropical and subtropical regions. Prevalence rates are extremely high in aboriginal tribes in Australia, in Africa, in South America, and in other developing regions of the world. Incidence in parts of Central America and South America and in one Indian village approach 100%. In parts of Bangladesh, the number of children with "the itch" exceeds the number with diarrheal and respiratory diseases combined.

Worldwide, the prevalence of scabies has been estimated at 300 million cases annually, although this figure may be an overestimate. In the United States and in other developed regions around the world, scabies occurs in epidemics in nursing homes, hospitals, long-term care facilities, and other institutions. It is seen frequently in the homeless populations but occurs episodically in other populations as well. No recent published data are available on its incidence in the United States. In one epidemiologic study in the United Kingdom, scabies was shown to have a higher frequency of occurrence in winter months than in summer months, and it more commonly affected women and children. In this study, the disease was found to be more prevalent in urban regions.

While scabies appears to be more common in the younger population, it certainly occurs in all ages, all ethnic groups, all socioeconomic levels, and in both sexes. It is not directly related to hygiene, but it is associated with poverty and crowding.

Mode of transmission

Mites are unable to fly or jump. They crawl at a rate of 2.5 cm/min. While the mite's life cycle occurs completely on its host, they are able to live on bedding, clothes, or other surfaces at room temperature for about 48 hours while remaining capable of infestation and burrowing. At temperatures below 20°C S scabiei are immobile, although they can survive such temperatures for extended periods.

Transmission is predominantly through direct skin-to-skin contact, and for this reason, scabies has been considered a sexually transmitted disease. Indirect contact through fomites such as infested bedding or clothing is possible, although not usual. However, the greater the number of parasites on a person, as in crusted scabies, the more likely that indirect contact will abet transmission of the disease.

Mortality/Morbidity

Classic scabies is primarily a nuisance. However, it can indirectly lead to long-term morbidity. Scabies and other parasitic skin diseases can lead to long-term colonization of skin lesions by group A streptococci. Several studies have demonstrated a correlation between poststreptococcal glomerulonephritis (PSGN) and scabies. Conversely, in one World Health Organization sponsored study in the Solomon Islands, an intervention of mass chemotherapy lead to a decrease of scabies by 96% and a parallel drop in an indicator of renal disease. In remote Aboriginal communities in Australia where scabies is endemic, the repeated infestations appear to be related to the extremely high levels of renal failure and rheumatic heart disease observed in the communities.

While the microbiology of secondary bacterial infection in scabies lesions probably changes based on geographic location, one study demonstrated that the predominant aerobic and facultative bacteria recovered from lesions were Staphylococcus aureus, group A streptococci, and Pseudomonas aeruginosa. Multiple anaerobes were recovered as well, suggesting polymicrobial colonization of lesions.

Other complications of scabies include impetigo, furunculosis, and cellulites. The staphylococci and/or streptococci in the lesions can lead to pyelonephritis, abscesses, pyogenic pneumonia, sepsis, and death.

CLINICAL

Section 3 of 11  

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History

• Suspect scabies in any patient, regardless of age or socioeconomic status, who presents with severe persistent pruritus. The patient with scabies has generally been itching for a short time. On the other hand, the infestation can persist indefinitely, thus the appellation "the seven year itch."
• Signs and symptoms tend to crescendo progressively over 2-3 weeks before compelling the patient to seek medical attention.
• In developed nations, scabies occurs more commonly in fall and winter months.
• Scabies appears to occur in clusters. If there is an outbreak in the community, consider scabies in an individual presenting with itching and a rash.
• Consider a diagnosis of scabies if multiple family members are involved.
• Nocturnal pruritus is a highly characteristic complaint associated with scabies infestation.
• While unusual in the neonate, scabies has been reported in this age group.

Physical

• Primary lesions
• • A short elevated serpiginous (S-shaped) track in the superficial epidermis, known as a burrow, is pathognomonic of scabies infestation.
  • Burrows or runs appear as a thin (approximately the width of a human hair), short (perhaps 2-3 mm in length), gray brown, wavy channel on the skin.
  • Occasionally, the mite is visible to the naked eye as a small white dot.
  • A small vesicle or papule may appear at the end of the burrow or occur independently.
  • Nodular scabies may erupt on covered parts of the body (see below) as either few or many lesions. They are characterized by firm, red nodules approximately 0.5 cm or larger.
  • Norwegian scabies presents with extensive crusting (psoriasiformlike lesions) of the skin with thick, hyperkeratotic scales overlying the elbows, knees, palms, and soles.
  • Bullous lesions may be observed in immunocompromised patients.
  • Canine scabies does not exhibit the classic burrow. Instead, papules and vesicles are the most prominent lesions surfacing on the arms, chest, abdomen, and thighs.
• Secondary lesions
• • Ordinarily, burrows are best detected in the web spaces of the fingers, flexor aspects of the wrists, antecubital fossa, axilla, umbilicus, buttocks, and feet.
  • In women, the nipples and areola of the breasts often are affected. In men, red papules or nodules on the penile glans, shaft, and scrotum are almost pathognomonic of scabies.
  • Compared to adults, scabies in infants and young children tend to be more disseminated and, while the head and face usually are spared in adults, they may be affected in the very young.
  • Nodular scabies presents exclusively on covered parts of the bodies, such as the scrotum, penis, buttocks, groin, axillary folds, and upper back.
  • Geriatric scabies demonstrates a propensity for the back, often appearing as excoriations.

Causes

• Scabies is caused by the mite S scabiei var hominis, an arthropod of the order Acarina.
• Animal forms of scabies exist and are generally referred to as mange. S scabiei causes mange in many companion and livestock animals and is responsible for epizootic diseases in wild populations of cats, ungulates, boars, wombats, ferrets, koalas, and great apes. It is considered to be a major cause of mortality among red foxes, coyotes, and wombat.
• Humans can be affected by animal scabies. Transient pruritic popular or vesicular erythremic lesions may occur after 24 hours of an exposure to an infested animal. The rapid sensitivity differs from primary infections in humans with the human variety of S scabiei. This may be due to previous sensitization in the human host. The immediate itching may lead to a protective mechanism in the human host—scratching—which can prevent the mite from burrowing.

DIFFERENTIALS

Section 4 of 11  

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Other Problems to be Considered

Classic scabies

Insect bites
Atopic dermatitis
Contact dermatitis
Psoriasis
Fiberglass exposure
Lichen planus
Dermatitis herpetiformis
Bullous pemphigoid
Urticaria
Chronic lymphocytic leukemia
Necrotizing vasculitis
B-cell lymphoma with monoclonal infiltrate

Crusted scabies

Eczema
Psoriasis
Ichthyosis
Adverse drug reactions
Seborrheic dermatitis
Erythroderma
Langerhans cell histiocytosis

WORKUP

Section 5 of 11  

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Lab Studies

• History and physical examination
• Diagnostic testing: Definitive testing relies on the identification of mites, eggs, eggshell fragments, or mite pellets. This is best undertaken by using a drop of mineral oil placed directly over the burrow and then scraping laterally across the skin with a scalpel blade. One should avoid causing bleeding. The sample is placed on a microscope slide and examined under both low and high power for the presence of adult mites, their eggs, or their scybala (fecal pellets). Potassium hydroxide should not be used since it can dissolve mite pellets.
• Failure to find mites is common and does not rule out the diagnosis of scabies. Other diagnostic tests include skin biopsy.
• Applying topical tetracycline to the skin and washing off the excess may reveal burrows. The burrows retain the tetracycline, which fluoresces under a Wood lamp, allowing easy identification.
• Rubbing a washable felt-tip marker across the suspected site and removing the ink with an alcohol wipe may also localize a burrow more precisely. When a burrow is present, the ink penetrates the stratum corneum and delineates the site.
• Videodermatoscopy, epiluminescence microscopy, and DNA amplification by polymerase chain reaction (PCR) followed by enzyme-linked immunosorbent assay (ELISA) are tools also used by some dermatologists in tertiary centers. These methods are not readily available in the emergency department or in many dermatology departments.
• Elevated immunoglobulin E (IgE) titers and eosinophilia may be demonstrated in some patients with scabies.

TREATMENT

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Emergency Department Care

• Prescribe an appropriate scabicide.
• Provide relief of symptoms. Itching may persist for 1-2 weeks, even following successful treatment. Pruritus may be alleviated partially with an oral antihistamine, such as hydroxyzine hydrochloride (Atarax), diphenhydramine hydrochloride (Benadryl), or cyproheptadine hydrochloride (Periactin).
• Treat secondary infections.
• Treat household members and close personal contacts.
• Provide reassurance that scabies is not a reflection of poor personal hygiene.

Consultations

Dermatology or infectious disease consultation may be required for severe refractory scabies or for disseminated scabies in patients with immunocompromise. Caution must be exercised when treating pregnant patients.

MEDICATION

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Scabicides should be prescribed for patients, household members, and close personal contacts. Symptomatic treatment may require antihistamines. More severe symptoms may require a short course of topical or oral steroids. Secondary infections may require antibiotics.

Drug Category: Scabicides

Treatment options include either topical or oral medication. Topical options include permethrin cream, lindane, benzyl benzoate, crotamiton lotion and cream, sulfur, Tea tree oil, oil of the leaves of Lippia multiflora Moldenke, a shrub found growing in West Africa Savannah. Oral options include ivermectin.

Permethrin is the drug of choice in the United States and the United Kingdom, but it is not available in France. In some studies, it has been shown to be more effective than a single dose of oral ivermectin, although it has equivalent efficacy when 2 doses of ivermectin are used at time zero and 2 weeks later.

Drug Name	Lindane (Kwell)
Description	Stimulates nervous system of parasite, causing seizures and death. Previous standard treatment for scabies but is now considered second-line treatment if other agents fail or are not tolerated. Not very safe in children due to transcutaneous absorption leading to neurotoxicity. Overall, permethrin is a safer choice.
Adult Dose	Apply thin layer from chin to toes; use on dry skin and shower off 10 h later; repeat in 1 wk
Pediatric Dose	Infants and children: Apply thin film topically over entire body including hairline, neck, scalp, temple, and forehead, leave on 6-8 h before washing off with water; may repeat in 1 wk if necessary; not to exceed 30 g/application
Contraindications	Documented hypersensitivity; neonates; acutely swollen skin or Norwegian scabies
Interactions	Oil-based hairdressings may increase toxicity
Pregnancy	B - Usually safe but benefits must outweigh the risks.
Precautions	Caution if history of seizures; do not apply to eyes, face, or mucous membranes; caution if history of keratinization/ichthyosis disorders

Drug Name	Sulfur in petrolatum (2 -10%, with 6% preferred)
Description	One of few effective scabicidal treatments that may be used safely without fear of toxicity in very small children and in pregnant women. Sulfur is messy, malodorous, and stains clothes, and requires repeat applications, thus reducing compliance. It can cause a dermatitis in hot and humid climates.
Adult Dose	Apply to entire body below head on 3 successive nights and bathe 24 h after each application
Pediatric Dose	Administer as in adults
Contraindications	Documented hypersensitivity
Interactions	None reported
Pregnancy	C - Safety for use during pregnancy has not been established.
Precautions	Resuscitative equipment should be immediately available when administering medication

Drug Name	Crotamiton (Eurax)
Description	For the treatment of scabies. Mechanism of action is unknown.
Adult Dose	Apply thin layer onto skin of entire body from neck to toes; repeat in 24 h; take a cleansing bath 48 h after last application
Pediatric Dose	Administer as in adults
Contraindications	Documented hypersensitivity; can cause seizures
Interactions	None reported
Pregnancy	C - Safety for use during pregnancy has not been established.
Precautions	Do not apply to face, urethral meatus, eyes, mucous membranes, or swollen skin; can cause seizures

Drug Name	Benzyl benzoate
Description	Ester of benzoic acid and benzyl alcohol. Neurotoxic to mites. Not available in the US but first line in France.
Adult Dose	Use 25% emulsion; apply below neck 3 times within 24 h without an intervening bath
Pediatric Dose	May reduce adult dose to 12.5% or less due to stinging
Contraindications	Documented hypersensitivity; breastfeeding women; infants and children <2 y
Interactions	None reported
Pregnancy	X - Contraindicated in pregnancy
Precautions	May cause stinging

Drug Name	Ivermectin (Mectizan, Stromectol)
Description	Binds selectively with glutamate-gated chloride ion channels in invertebrate nerve and muscle cells, causing cell death. Half-life is 16 h; metabolized in liver. First-line therapy.
Adult Dose	150-200 mcg/kg/d PO as single dose
Pediatric Dose	<5 years: Not established >5 years: Administer as in adults
Contraindications	Documented hypersensitivity
Interactions	May interact with other ligand-gated chloride channels, such as those gated by GABA
Pregnancy	C - Safety for use during pregnancy has not been established.
Precautions	Treat mothers who intend to breastfeed only when risk of delayed treatment outweighs possible risks to the newborn caused by ivermectin excretion in milk Repeat courses of therapy may be required in immunocompromised patients May cause nausea, vomiting, and mild CNS depression; may cause drowsiness

FOLLOW-UP

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Deterrence/Prevention

• All household members and close personal contacts should be treated, whether or not they are symptomatic.
• Bedding, towels, and clothing should be washed in 60°C (or higher) water and then machine dried.
• If items cannot be washed, they should be isolated for 3 or more days.
• Patients should be reexamined 2 weeks after treatment to evaluate effectiveness.

Complications

• Persistent symptoms may last up to 2-4 weeks after treatment. Residual pruritus may require antihistamines or a short course of topical or oral steroids. If symptoms last greater than 4 weeks, several possibilities exist:
• • Treatment failure (see below)
  • Allergic dermatitis due to the topical medicine used
  • Ordinary household mites can cause a cross reactivity and can drive persistent symptoms
  • Acarophobia: Delusional parasitosis; requires psychiatric intervention
  • Secondary infection requiring antibiotics
• Treatment failures are uncommon but do occur. The most common causes of treatment failure include the following:
• • Improper application
  • Inadequate application
  • Reinfestation: Recurrence of the eruption usually means reinfection has occurred.
  • Resistance: Resistance to lindane has been widely reported. Less frequently, cases of resistance to permethrin have been noted. Resistance to ivermectin is still rare but has been reported in patients who have received multiple doses of the drug over several years.
• Scabetic nodules may require intranodular steroid injection.

Patient Education

• For excellent patient education resources, visit eMedicine's Infections Center. Also, see eMedicine's patient education article Scabies.
• Additional information can be gleaned through the CDC Division of Parasitic Diseases, Scabies.

MISCELLANEOUS

Section 9 of 11  

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Medical/Legal Pitfalls

• Failure to consider scabies because of minimal skin findings is a pitfall. Always consider scabies infestation in patients with intense pruritus, especially when a sexual partner or other family members are similarly affected.

Special Concerns

• Norwegian scabies demonstrates a predilection for immunocompromised, elderly, debilitated, and institutionalized patients.
• Canine scabies does not present with the classic burrow.
• In infants, eczematous eruptions may appear on the face. In contrast, the head and neck are almost never involved in older children, adolescents, or adults.

MULTIMEDIA

Section 10 of 11  

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• Multimedia
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Media file 1:  Scabies mite. Courtesy of William D. James, MD.
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Media file 2:  Scabies mite scraped from a burrow (original magnification 400X). Courtesy of Audra Malerba, DO.
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Media file 3:  Scabies. Courtesy of William D. James, MD.
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Media file 4:  In crusted scabies, sections show multiple mites (arrows) within the hyperkeratotic stratum corneum (H&E, original magnification 100X). The epidermis is spongiotic. Courtesy of Audra Malerba, DO.
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Media file 5:  In routine scabies, a single mite is seen. Eosinophilic spongiosis may be present (H&E, original magnification 400X). Courtesy of Audra Malerba, DO.
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Media file 6:  Norwegian scabies. Courtesy of William D. James, MD.
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Media file 7:  Scabies on leg. Courtesy of William D. James, MD.
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Media file 8:  Erythematous vesicles and papules are present on torso extremities, some with adjacent linear excoriations. Courtesy of Audra Malerba, DO.
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Media file 9:  Scabies on buttocks. Courtesy of William D. James, MD.
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Media file 10:  Scabies on hand. Courtesy of William D. James, MD.
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Media file 11:  Scabies on penis. Courtesy of William D. James, MD.
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Media file 12:  Scabies on penis. Courtesy of Hon Pak, MD.
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REFERENCES

Section 11 of 11

• Authors and Editors
• Introduction
• Clinical
• Differentials
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• Lawrence G, Leafasia J, Sheridan J, et al. Control of scabies, skin sores and haematuria in children in the Solomon Islands: another role for ivermectin. Bull World Health Organ. Jan 2005;83(1):34-42. [Medline].
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• Scabies fact sheet. Atlanta: Centers for Disease Control and Prevention, 2005. [Full Text].
• Schleicher SM, Stewart P. Scabies: The mite that roars. Emerg Med. 1997;6:54-8.
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Article Last Updated: Jun 19, 2006